The Red Wings were doubled up by the Panthers 6-3 Thursday night in Florida.
Dylan Larken scored twice to notch the first multi-goal game of his career, while Mike Green added a goal in the third.
Jimmy Howard stopped 27 shots in the loss.
The Wings dropped both games during their Florida road-trip, losing to the Lightning in Tampa Wednesday.
Detroit returns to Joe Louis Arena to host the Islanders Saturday.
New York Rangers 4, Minnesota Wild 2
Boston Bruins 3, Buffalo Sabres 2 (SO)
Florida Panthers 6, Detroit Red Wings 3
Edmonton Oilers 7, Ottawa Senators 2
Toronto Maple Leafs 3, New Jersey Devils 2 (SO)
Washington Capitals 3, New York Islanders 2
San Jose Sharks 3, St. Louis Blues 1
Philadelphia Flyers 6, Nashville Predators 3
Chicago Blackhawks 5, Arizona Coyotes 4 (OT)
Dallas Stars 4, Colorado Avalanche 3 (OT)
Anaheim Ducks 4, Los Angeles Kings 2
Columbus Blue Jackets 2, Vancouver Canucks 1 (SO)
By: Mike Plourde – for Great Lakes Radio Sports