Tobias Harris scored a game-high 22 points and grabbed eight rebounds as the Pistons cruised past the 76ers, 111-91 Wednesday night.
Andre Drummond posted 12 points and 18 boards for the Pistons, who have won two in-a-row since a five-game losing streak.
Reggie Jackson netted 17 points and Reggie Bullock had 16 in the rout.
Hollis Thompson recorded 19 points off the bench to pace Philadelphia, which fell to 8-and-49.
The Pistons will travel to Milwaukee to take on the Bucks Saturday.
The Pistons will be without forwards Stanley Johnson and Anthony Tolliver for several games because of injuries.
Johnson will be out at least a week with a right shoulder sprain and Tolliver will be sidelined up to four weeks with a knee injury.
To help fill the roster spots, Detroit signed forward Justin Harper from the NBA Development League to a 10-day contract.
Harper, who was on the Pistons summer-league roster the last two years, averaged 14.8 points and 5 rebounds in 34 games this season with the Los Angeles D-Fenders.
Cleveland Cavaliers 114, Charlotte Hornets 103
Indiana Pacers 108, New York Knicks 105
Detroit Pistons 111, Philadelphia 76ers 91
Golden State Warriors 118, Miami Heat 112
Toronto Raptors 114, Minnesota Timberwolves 105
Chicago Bulls 109, Washington Wizards 104
Memphis Grizzlies 128, Los Angeles Lakers 119
Oklahoma City Thunder 116, Dallas Mavericks 103
Denver Nuggets 87, Los Angeles Clippers 81
San Antonio Spurs 108, Sacramento Kings 92
By: Mike Plourde – for Great Lakes Radio Sports